Bande, O., Abu El Asrar, R., Braddick, D., Dumbre, S., Pezo, V., Schepers, G., Pinheiro, V.B., Lescrinier, E., Holliger, P., Marlière, P. and Herdewijn, P. Isoguanine and 5-Methyl-Isocytosine Bases, In Vitro and In Vivo. Chemistry – A European Journal, (2015)


Taylor, A.I., Pinheiro, V.B., Smola, M.J., Morgunov, A.S., Peak-Chew, S., Cozens, C., Weeks, K.M., Herdewijn, P. and Holliger, P. Catalysts from synthetic genetic polymers, Nature (2014).

Pinheiro, V.B.*, Arangundy-Franklin, S., and Holliger, P., Compartmentalized self-tagging for in vitro directed evolution of XNA polymerases, Current Protocols in Nucleic Acid Chemistry, UNIT 9.9 (2014). *corresponding author.

Pinheiro, V.B. and Holliger, P., Towards XNA nanotechnology: new materials from synthetic genetic polymers, Trends in Biotechnology32(6), 321 (2014).


Wynne, S.A., Pinheiro, V.B., Holliger, P. and Leslie, A.G.W. Structures of an Apo and a Binary Complex of an Evolved Archeal B Family DNA Polymerase Capable of Synthesising Highly Cy-Dye Labelled DNA. PLoS ONE, 8(8): e70892 (2013).

Pinheiro, V.B.*, Loakes, D. and Holliger, P., Synthetic polymers and their potential as genetic materials. Bioessays, 35, 113(2013). *corresponding author.


Pinheiro, V.B. and Holliger, P., The XNA world: Progress towards replication and evolution of synthetic genetic polymers. Current Opinion in Chemical Biology, 16, 245 (2012).

Cozens, C., Pinheiro, V.B., Vaisman, A., Woodgate, R. and Holliger, P., A short adaptive path from DNA to RNA polymerases. PNAS, 109, 8067 (2012).

Pinheiro, V.B., Taylor A.I., Cozens, C., Abramov, M., Renders, M., Zhang, S., Chaput, J., Wengel, J., Peak-Chew, S-Y., McLaughlin, S.H., Herdewijn, P. and Holliger, P., Synthetic genetic polymers capable of heredity and evolution. Science, 336, 341 (2012).

Pinheiro, V.B., Ong, J.L. and Holliger, P., Polymerase engineering: From PCR and sequencing to synthetic biology. Protein Engineering Handbook, volume III, chapter 12. Edited by Stefan Lutz. Wiley-VCH, Weinheim (2012). ISBN: 978-3-527-33123-9


Attwater, J., Wochner, A., Pinheiro, V.B., Coulson, A. and Holliger, P., Ice as a protocellular medium for RNA replication. Nature Communications, 1, 1 (2010).

2009 and earlier

Loakes, D., Gallego, J., Pinheiro, V.B., Kool, E.T. and Holliger, P., Evolving a polymerase for hydrophobic base analogues. Journal of the American Chemical Society, 131, 14827 (2010).

Pinheiro, V.B. and Ellar, D.J., Expression and insecticidal activity of Yersinia pseudotuberculosis and Photorhabdus luminescens toxin complex proteins. Cellular Microbiology, 9, 2372 (2007).

Pinheiro, V.B. and Ellar, D.J., How to kill a mocking bug? Cellular Microbiology, 8, 545 (2006).

Vitor Pinheiro

Vitor Pinheiro